Jennifer Hogan

User Profile

Name: Jennifer Hogan

Member Since: October 11th, 2011

Member Name: jenhogan

Last Logged In: March 29th, 2012

Biography:

Jennifer N. Hogan

1406 Henry St., Apt. M, Berkeley, CA 94709

cell: (650) 430-8741 jnhogan@ucdavis.edu

Education

University of California, Davis Epidemiology Ph.D. Candidate Sept 2007-present

Gonzaga University Bachelor of Science: Biology Minor: Sociology May 2005

Dean’s List: Spring 2004, Fall 2004, Spring 2005

Technical Skills

Math and Computer Skills: SAS Statistical Software, ArcGIS, SaTScan, Study Director, GraphPad Prism, Word,

PowerPoint, Excel, Adobe Photoshop, Adobe Illustrator

Laboratory Skills: RNA isolation and purification, gel electrophoresis, DNA and protein isolation, PCR,

immunomagnetic separation (IMS), fecal floatation

Slide Preparation and Staining: Microtome and water-bath techniques, Cryostat usage, H&E,

immunohistochemistry, direct fluorescent antibody staining (DFA)

In Vivo: intraperitoneal, intravenous, subcutaneous and oral dosing using mouse models; tumor and weight

measurements, terminal cardiac blood collection, gross necropsy, organ and tumor collection, experience

with athymic nude, SCID, NIH3, and conventional mouse strains

Tissue Culture: maintaining stable cell lines, cell counts, sterile technique, cell implantation into mouse models

Experience

Graduate Student Researcher

Veterinary Medicine: PMI, UC Davis, CA (02/08-present)

• As a California Sea Grant Trainee, evaluated the efficacy of wetlands in protozoal removal through

developing methodology to examine protozoa transport and surveying protozoa contamination in

wetlands through sample collection in the field, IMS and DFA processing, and microscopy analysis.

• Collaborated with the Mountain Gorilla Veterinary Project in Rwanda to evaluate fecal protozoal

transmission in sympatric species in the Virunga National Park.

• Analyzed protozoa counts with applied Poisson and Negative Binomial regression methods using SAS

and examined spatial relationships using SatScan and ArcGIS programming.

Staff Research Associate I,

Pharmacology Department, Sunesis Pharmaceuticals, South San Francisco, CA (06/05-08/07)

• Performed in vivo studies to support pre-clinical Aurora Kinase Inhibitor program.

• Maintained a library of human cancer cell lines and directed implantation of cancer cell lines for in vivo

studies in athymic nude mice.

• Performed intraperitoneal (IP), intravenous (IV), and oral (PO) dosing of athymic nude mice, tumor and

terminal blood collection, gross necropsy, and tumor volume and weight measurements for xenograft,

growth curve, and target modulation studies.

• Developed a process for immunohistochemical tumor sample analysis to support development projects.

Research Laboratory Intern,

Molecular Oncology Department, Genentech, South San Francisco, CA (05/04-08/04)

• Maintained populations of stable cell lines.

• Monitored tumor growth size and weight of athymic nude mice.

• Isolated and purified RNA, DNA, and protein for analysis.

Field Assistant,

Lumina Technologies, Santa Rosa, CA (07/03-05/05)

• Evaluated sites for possible environmental contamination.

• Compiled information for Environmental Impact Reports through site surveys and toxic record and

environmental record searches.

• Collected sound and light level measurement data, and performed biology and botany surveys.

Biology Teaching Experience,

Gonzaga University, Spokane, WA

Biology Tutor for Biology 101 and 102 (09/03-05/05)

• Clarified and identified questions students had in these classes and facilitated study groups.

• Helped students’ comprehension and encouraged them to adopt successful study strategies.

Biology Lab Teaching Assistant for Biology 101 and 102 (01/03-05/05)

• Instructed students in various laboratory skills essential to biological and ecological study.

• Created weekly quizzes, and was in charge of in-class assignments and grading.

Awards Received

UC Davis and Humanities Graduate Research Fellowship, 2011-2012

Graduate Group of Epidemiology Fellowship, 2011-2012

Graduate Student Travel Award 2011

Wildlife Health Center Fellowship 2010-2011

Graduate Group of Epidemiology Block Grant, 2007, 2008, 2009, 2010

Published Literature

Epidemiology of Cryptosporidium, Giardia, and fecal indicator bacteria in coastal California wetland ecosystems.

Hogan JN, Daniels ME, Watson FG, Conrad PA, Oates SC, Miller MA, Hardin D, Byrne BA, Dominik C,

Melli A, Jessup DA, Miller WA. In preparation.

SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo.

Arbitrario JP, Belmont BJ, Evanchik MJ, Flanagan WM, Fucini RV, Hansen SK, Harris SO, Hashash A,

Hoch U, Hogan JN, Howlett AR, Jacobs JW, Lam JW, Ritchie SC, Romanowski MJ, Silverman JA, Stockett

DE, Teague JN, Zimmerman KM, Taverna P. Cancer Chemother Pharmacol. 2009 Aug 65(4):707-17.

The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy

with microtubule-targeted agents in a colon carcinoma model. VanderPorten EC, Taverna P, Hogan JN,

Ballinger MD, Flanagan WM, Fucini RV. Mol Cancer Ther. 2009 Apr;8(4):930-9.

Abstracts Presented

Giardia in Sympatric Wildlife in Volcanoes National Park, Rwanda. Hogan J, Hassell J, Noheri, JB, Ramer J,

Cranfield M, Miller W, Gilardi K. Wildlife Disease Association Annual Meeting: Quebec City, Canada,

August 14-19, 2011

Waterborne Protozoal Removal by Coastal California Wetlands. Hogan J, Daniels M, Watson F, Conrad P,

Miller, W. American Society of Parasitology Annual Meeting: Anchorage, AK, June 1-4, 2011.

Reaching across disciplines to form a one health team using the Mountain Gorilla One Health Program

(MGOHP) case study. Hogan J, Harris L. Global Health: Breaking Borders and Boundaries: Davis, CA,

April 9, 2011.

Waterborne Protozoal Removal by Coastal California Wetlands. Hogan J, Daniels M, Watson F, Conrad P,

Miller, W. EPA National Beach Conference: Miami, FL, March 14-17, 2011.

SNS-314, a selective Aurora kinase inhibitor with potent, pre-clinical anti-tumor activity, shows broad

therapeutic potential in combination with standard chemotherapeutics and synergy with microtubule

targeted agents. E. Chan, R. Fucini, K. Zimmerman, M. Bui, J. Hogan, M. Jackson, P. Taverna, M.

Ballinger, A. Howlett, M. Flanagan. European Cancer Conference, ECCO: Barcelona, Spain, September 23-

27, 2007.

SNS-314, a potent inhibitor of Aurora kinases, shows broad anti-tumor activity and dosing flexibility in vivo.

Jennifer N. Hogan, Jeffrey L. Kumer, Jennifer P. Arbitrario, Ute Hoch, Jeffrey A. Silverman, Anthony R.

Howlett and Pietro Taverna. International Symposium on Targeted Anticancer Therapies: Amsterdam, the

Netherlands, March 8-10, 2007.

SNS-314, a novel small-molecule Aurora kinase inhibitor, induces cell cycle defects and potently suppresses

tumor growth. K. Gamo, B. Belmont, D. Stockett, B.T. Tangonan, M.J. Romanowski, W. Lew, S. Baskaran,

C. Yu, E. Hanan, J. Oslob, M. Bui, M. Zhong, S. Heumann, D. Allen, W. Shen, J. Hogan, J. Kumer, A.

Howlett, T. O’Brien, W.M. Flanagan, Keystone Symposia, Molecular Targets for Cancer (X3): Whistler,

British Columbia, March 18-23, 2007.