Health effects of cobalt


Cobalt is a naturally-occurring element that has properties similar to those of iron and nickel. It has an atomic number of 27. There is only one stable isotope of cobalt, which has an atomic mass number of 59. (An element may have several different forms, called isotopes, with different weights depending on the number of neutrons that it contains. The isotopes of an element, therefore, have different atomic mass numbers [number of protons and neutrons], although the atomic number [number of protons] remains the same.) However, there are many unstable or radioactive isotopes, two of which are commercially important, cobalt 60 and cobalt 57, also written as Co 60 or 60Co and Co 57 or 57Co, and read as cobalt sixty and cobalt fifty-seven. All isotopes of cobalt behave the same chemically and will therefore have the same chemical behavior in the environment and the same chemical effects on your body. However, isotopes have different mass numbers and the radioactive isotopes have different radioactive properties, such as their half-life and the nature of the radiation they give off. The half-life of a cobalt isotope is the time that it takes for half of that isotope to give off its radiation and change into a different isotope. After one half-life, one-half of the radioactivity is gone. After a second half-life, one-fourth of the original radioactivity is left, and so on. Radioactive isotopes are constantly changing into different isotopes by giving off radiation, a process referred to as radioactive decay. The new isotope may be a different element or the same element with a different mass.

Small amounts of cobalt are naturally found in most rocks, soil, water, plants, and animals, typically in small amounts. Cobalt is also found in meteorites. Elemental cobalt is a hard, silvery grey metal. However, cobalt is usually found in the environment combined with other elements such as oxygen, sulfur, and arsenic. Small amounts of these chemical compounds can be found in rocks, soil, plants, and animals. Cobalt is even found in water in dissolved or ionic form, typically in small amounts. (Ions are atoms, collections of atoms, or molecules containing a positive or negative electric charge.) A biochemically important cobalt compound is vitamin B12 or cyanocobalamin. Vitamin B12 is essential for good health in animals and humans. Cobalt is not currently mined in the United States, but has been mined in the past. Therefore, we obtain cobalt and its other chemical forms from imported materials and by recycling scrap metal that contains cobalt.

Cobalt metal is usually mixed with other metals to form alloys, which are harder or more resistant to wear and corrosion. These alloys are used in a number of military and industrial applications such as aircraft engines, magnets, and grinding and cutting tools. They are also used in artificial hip and knee joints. Cobalt compounds are used as colorants in glass, ceramics, and paints, as catalysts, and as paint driers. Cobalt colorants have a characteristic blue color; however, not all cobalt compounds are blue. Cobalt compounds are also used as trace element additives in agriculture and medicine.

Cobalt can also exist in radioactive forms. A radioactive isotope of an element constantly gives off radiation, which can change it into an isotope of a different element or a different isotope of the same element. This newly formed nuclide may be stable or radioactive. This process is called radioactive decay. 60Co is the most important radioisotope of cobalt. It is produced by bombarding natural cobalt, 59Co, with neutrons in a nuclear reactor. 60Co decays by giving off a beta ray (or electron), and is changed into a stable nuclide of nickel (atomic number 28). The half-life of 60Co is 5.27 years. The decay is accompanied by the emission of high energy radiation called gamma rays. 60Co is used as a source of gamma rays for sterilizing medical equipment and consumer products, radiation therapy for treating cancer patients, and for manufacturing plastics. 60Co has also been used for food irradiation; depending on the radiation dose, this process may be used to sterilize food, destroy pathogens, extend the shelf-life of food, disinfest fruits and grain, delay ripening, and retard sprouting (e.g., potatoes and onions). 57Co is used in medical and scientific research and has a half-life of 272 days. 57Co undergoes a decay process called electron capture to form a stable isotope of iron (57Fe). Another important cobalt isotope, 58Co, is produced when nickel is exposed to a source of neutrons. Since nickel is used in nuclear reactors, 58Co may be unintentionally produced and appear as a contaminant in cooling water released by nuclear reactors. 58Co also decays by electron capture, forming another stable isotope of iron (58Fe). 60Co may be similarly produced from cobalt alloys in nuclear reactors and released as a contaminant in cooling water. 58Co has a half-life of 71 days and gives off beta and gamma radiation in the decay process.

Quantities of radioactive cobalt are normally measured in units of radioactivity (curies or becquerels) rather than in units of mass (grams). The becquerel (Bq) is a new international unit, and the curie (Ci) is the traditional unit; both are currently used. A becquerel is the amount of radioactive material in which 1 atom transforms every second, and a curie is the amount of radioactive material in which 37 billion atoms transform every second.

Pathways for cobalt in the environment

Cobalt may enter the environment from both natural sources and human activities. Cobalt occurs naturally in soil, rock, air, water, plants, and animals. It may enter air and water, and settle on land from windblown dust, seawater spray, volcanic eruptions, and forest fires and may additionally get into surface water from runoff and leaching when rainwater washes through soil and rock containing cobalt. Soils near ore deposits, phosphate rocks, or ore smelting facilities, and soils contaminated by airport traffic, highway traffic, or other industrial pollution may contain high concentrations of cobalt. Small amounts of cobalt may be released into the atmosphere from coal-fired power plants and incinerators, vehicular exhaust, industrial activities relating to the mining and processing of cobalt-containing ores, and the production and use of cobalt alloys and chemicals. 58Co and 60Co may be released to the environment as a result of nuclear accidents (i.e, Chernobyl), radioactive waste dumping in the sea or from radioactive waste landfills, and nuclear power plant operations.

Cobalt cannot be destroyed in the environment. It can only change its form or become attached or separated from particles. Cobalt released from power plants and other combustion processes is usually attached to very small particles. Cobalt contained in windborne soil is generally found in larger particles than those released from power plants. These large particles settle to the ground or are washed out of the air by rain. Cobalt that is attached to very small particles may stay in the air for many days. Cobalt released into water may stick to particles in the water column or to the sediment at the bottom of the body of water into which it was released, or remain in the water column in ionic form. The specific fate of cobalt will depend on many factors such as the chemistry of the water and sediment at a site as well as the cobalt concentration and water flow. Cobalt deposited on soil is often strongly attached to soil particles and therefore would not travel very far into the ground. However, the form of the cobalt and the nature of the soil at a particular site will affect how far cobalt will penetrate into the soil. Both in soil and sediment, the amount of cobalt that is mobile will increase under more acidic conditions. Ultimately, most cobalt ends up in the soil or sediment.

Plants can accumulate very small amounts of cobalt from the soil, especially in the parts of the plant that you eat most often, such as the fruit, grain, and seeds. While animals that eat these plants will accumulate cobalt, cobalt is not known to biomagnify (produce increasingly higher concentrations) up the food chain. Therefore, vegetables, fruits, fish, and meat that you consume will generally not contain high amounts of cobalt. Cobalt is an essential element, required for good health in animals and humans, and therefore, it is important that foodstuffs contain adequate quantities of cobalt.

60Co and 58Co are moderately short-lived, manufactured radioactive isotopes that are produced in nuclear reactors. Although these isotopes are not produced by nuclear fission, small amounts of these radioisotopes are also produced by the neutron interaction with the structural materials found in the reactor of nuclear plants, and are produced during the routine operation of nuclear plants. Small amounts may be released to the environment as contaminants in cooling water or in radioactive waste. Since these isotopes are not fission products, they are not produced in nuclear weapons testing and are not associated with nuclear fallout. In the environment, radioactive isotopes of cobalt will behave chemically like stable cobalt. However, 60Co and 58Co will also undergo radioactive decay according to their respective half-lives, 5.27 years and 71 days.

Exposure to cobalt

Cobalt is widely dispersed in the environment in low concentrations. You may be exposed to small amounts of cobalt by breathing air, drinking water, and eating food containing it. Children may also be exposed to cobalt by eating dirt. You may also be exposed by skin contact with soil, water, cobalt alloys, or other substances that contain cobalt. Analytical methods used by scientists to determine the levels of cobalt in the environment generally do not determine the specific chemical form of cobalt present. Therefore, we do not always know the chemical form of cobalt to which a person may be exposed. Similarly, we do not know what forms of cobalt are present at hazardous waste sites. Some forms of cobalt may be insoluble or so tightly attached to particles or embedded in minerals that they are not taken up by plants and animals. Other forms of cobalt that are weakly attached to particles may be taken up by plants and animals.

The concentration of cobalt in soil varies widely, generally ranging from about 1 to 40 ppm (1 ppm=1 part of cobalt in a million parts of soil by weight), with an average level of 7 ppm. Soils containing less than about 3 ppm of cobalt are considered cobalt-deficient because plants growing in them do not have sufficient cobalt to meet the dietary requirements of cattle and sheep. Such cobalt-deficient soils are found in some areas in the southeast and northeast parts of the United States. On the other hand, soils near cobalt-containing mineral deposits, mining and smelting facilities, or industries manufacturing or using cobalt alloys or chemicals may contain much higher levels of cobalt.

Usually, the air contains very small amounts of cobalt, less than 2 nanograms (1 nanogram=one-billionth part of a gram) per cubic meter (ng/m3). The amount of cobalt that you breathe in a day is much less than what you consume in food and water. You may breathe in higher levels of cobalt in dust in areas near cobalt-related industries or near certain hazardous waste sites.

The concentration of cobalt in surface and groundwater in the United States is generally low-between 1 and 10 parts of cobalt in 1 billion parts of water (ppb) in populated areas; concentration may be hundreds or thousands times higher in areas that are rich in cobalt-containing minerals or in areas near mining or smelting operations. In most drinking water, cobalt levels are less than 1-2 ppb.

For most people, food is the largest source of cobalt intake. The average person consumes about 11 micrograms of cobalt a day in their diet. Included in this food is vitamin B12, which is found in meat and diary products. The recommended daily intake of vitamin B12 is 6 micrograms (1 microgram=one-millionth part of a gram).

You may also be exposed to higher levels of cobalt if you work in metal mining, smelting, and refining, in industries that make or use cutting or grinding tools, or in other industries that produce or use cobalt metal and cobalt compounds. If good industrial hygiene is practiced, such as the use of exhaust systems in the workplace, exposure can be reduced to safe levels. Industrial exposure results mainly from breathing cobalt-containing dust.

When we speak of exposure to 60Co, we are interested in exposure to the radiation given off by this isotope, primarily the gamma rays. The general population is rarely exposed to this radiation unless a person is undergoing radiation therapy. However, workers at nuclear facilities, irradiation facilities, or nuclear waste storage sites may be exposed to 60Co or 58Co. Exposures to radiation at these facilities are regulated and carefully monitored and controlled.

Pathways for cobalt in the body

Cobalt can enter your body when you breathe in air containing cobalt dust, when you drink water that contains cobalt, when you eat food that contains cobalt, or when your skin touches materials that contain cobalt. If you breathe in air that contains cobalt dust, the amount of inhaled cobalt that stays in your lungs depends on the size of the dust particles. The amount that is then absorbed into your blood depends on how well the particles dissolve. If the particles dissolve easily, then it is easier for the cobalt to pass into your blood from the particles in your lungs. If the particles dissolve slowly, then they will remain in your lungs longer. Some of the particles will leave your lungs as they normally clean themselves out. Some of the particles will be swallowed into your stomach. The most likely way you will be exposed to excess cobalt is by eating contaminated food or drinking contaminated water. Levels of cobalt normally found in the environment, however, are not high enough to result in excess amounts of cobalt in food or water. The amount of cobalt that is absorbed into your body from food or water depends on many things including your state of health, the amount you eat or drink, and the number of days, weeks, or years you eat foods or drink fluids containing cobalt. If you do not have enough iron in your body, the body may absorb more cobalt from the foods you eat. Once cobalt enters your body, it is distributed into all tissues, but mainly into the liver, kidney, and bones. After cobalt is breathed in or eaten, some of it leaves the body quickly in the feces. The rest is absorbed into the blood and then into the tissues throughout the body. The absorbed cobalt leaves the body slowly, mainly in the urine. Studies have shown that cobalt does not readily enter the body through normal skin, but it can if the skin has been cut.

Health effects of cobalt

To protect the public from the harmful effects of toxic chemicals and to find ways to treat people who have been harmed, scientists use many tests.

One way to see if a chemical will hurt people is to learn how the chemical is absorbed, used, and released by the body. In the case of a radioactive chemical, it is also important to gather information concerning the radiation dose and dose rate to the body. You should know that one way to learn whether a chemical will harm people is to determine how the body absorbs, uses, and releases the chemical. For some chemicals, animal testing may be necessary. Animal testing may also help identify such health effects as cancer or birth defects. Without laboratory animals, scientists would lose a basic method for getting information needed to make wise decisions that protect public health. Scientists have the responsibility to treat research animals with care and compassion. Scientists must comply with strict animal care guidelines because laws today protect the welfare of research animals.

Additionally, there are vigorous national and international efforts to develop alternatives to animal testing. The efforts focus on both in vitro and in silico approaches and methods. For example, the National Toxicology Program (NTP) at the National Institute of Environmental Health Sciences (NIEHS) created the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) in 1998. The role of NICEATM is to serve the needs of high quality, credible science by facilitating development and validation—and regulatory and public acceptance—of innovative, revised test methods that reduce, refine, and replace the use of animals in testing while strengthening protection of human health, animal health and welfare, and the environment. In Europe, similar efforts at developing alternatives to animal based testing are taking place under the aegis of the European Centre for the Validation of Alternative Methods (ECVAM).

Cobalt has both beneficial and harmful effects on human health. Cobalt is beneficial for humans because it is part of vitamin B12, which is essential to maintain human health. Cobalt (0.16-1.0 mg cobalt/kg of body weight) has also been used as a treatment for anemia (less than normal number of red blood cells), including in pregnant women, because it causes red blood cells to be produced. Cobalt also increases red blood cell production in healthy people, but only at very high exposure levels. Cobalt is also essential for the health of various animals, such as cattle and sheep. Exposure of humans and animals to levels of cobalt normally found in the environment is not harmful.

When too much cobalt is taken into your body, however, harmful health effects can occur. Workers who breathed air containing 0.038 mg cobalt/m3 (about 100,000 times the concentration normally found in ambient air) for 6 hours had trouble breathing. Serious effects on the lungs, including asthma, pneumonia, and wheezing, have been found in people exposed to 0.005 mg cobalt/m3 while working with hard metal, a cobalt-tungsten carbide alloy. People exposed to 0.007 mg cobalt/m3 at work have also developed allergies to cobalt that resulted in asthma and skin rashes. The general public, however, is not likely to be exposed to the same type or amount of cobalt dust that caused these effects in workers.

In the 1960s, some breweries added cobalt salts to beer to stabilize the foam (resulting in exposures of 0.04-0.14 mg cobalt/kg). Some people who drank excessive amounts of beer (8-25 pints/day) experienced serious effects on the heart. In some cases, these effects resulted in death. Nausea and vomiting were usually reported before the effects on the heart were noticed. Cobalt is no longer added to beer so you will not be exposed from this source. The effects on the heart, however, may have also been due to the fact that the beer-drinkers had protein-poor diets and may have already had heart damage from alcohol abuse. Effects on the heart were not seen, however, in people with anemia treated with up to 1 mg cobalt/kg, or in pregnant women with anemia treated with 0.6 mg cobalt/kg. Effects on the thyroid were found in people exposed to 0.5 mg cobalt/kg for a few weeks. Vision problems were found in one man following treatment with 1.3 mg cobalt/kg for 6 weeks, but this effect has not been seen in other human or animal studies.

Being exposed to radioactive cobalt may be very dangerous to your health. If you come near radioactive cobalt, cells in your body can become damaged from gamma rays that can penetrate your entire body, even if you do not touch the radioactive cobalt. Radiation from radioactive cobalt can also damage cells in your body if you eat, drink, breathe, or touch anything that contains radioactive cobalt. The amount of damage depends on the amount of radiation to which you are exposed, which is related to the amount of activity in the radioactive material and the length of time that you are exposed. Most of the information regarding health effects from exposure to radiation comes from exposures for only short time periods. The risk of damage from exposure to very low levels of radiation for long time periods is not known. If you are exposed to enough radiation, you might experience a reduction in white blood cell number, which could lower your resistance to infections. Your skin might blister or burn, and you may lose hair from the exposed areas. This happens to cancer patients treated with large amounts of radiation to kill cancer. Cells in your reproductive system could become damaged and cause temporary sterility. Exposure to lower levels of radiation might cause nausea, and higher levels can cause vomiting, diarrhea, bleeding, coma, and even death. Exposure to radiation can also cause changes in the genetic materials within cells and may result in the development of some types of cancer.

Studies in animals suggest that exposure to high amounts of nonradioactive cobalt during pregnancy might affect the health of the developing fetus. Birth defects, however, have not been found in children born to mothers who were treated with cobalt for anemia during pregnancy. The doses of cobalt used in the animal studies were much higher than the amounts of cobalt to which humans would normally be exposed.

Nonradioactive cobalt has not been found to cause cancer in humans or in animals following exposure in the food or water. Cancer has been shown, however, in animals who breathed cobalt or when cobalt was placed directly into the muscle or under the skin. Based on the animal data, the International Agency for Research on Cancer (IARC) has determined that cobalt is possibly carcinogenic to humans.

Much of our knowledge of cobalt toxicity is based on animal studies. Cobalt is essential for the growth and development of certain animals, such as cows and sheep. Short-term exposure of rats to high levels of cobalt in the air results in death and lung damage. Longer-term exposure of rats, guinea pigs, hamsters, and pigs to lower levels of cobalt in the air results in lung damage and an increase in red blood cells. Short-term exposure of rats to high levels of cobalt in the food or drinking water results in effects on the blood, liver, kidneys, and heart. Longer-term exposure of rats, mice, and guinea pigs to lower levels of cobalt in the food or drinking water results in effects on the same tissues (heart, liver, kidneys, and blood) as well as the testes, and also causes effects on behavior. Sores were seen on the skin of guinea pigs following skin contact with cobalt for 18 days. Generally, cobalt compounds that dissolve easily in water are more harmful than those that are hard to dissolve in water.

Much of what we know about the effects of radioactive cobalt comes from studies in animals. The greatest danger of radiation seen in animals is the risk to the developing animal, with even moderate amounts of radiation causing changes in the fetus. High radiation doses in animals have also been shown to cause temporary or permanent sterility and changes in the lungs, which affected the animals' breathing. The blood of exposed animals has lower numbers of white blood cells, the cells that aid in resistance to infections, and red blood cells, which carry oxygen in the blood. Radioactive cobalt exposures in animals have also caused genetic damage to cells, cancer, and even death.

Health effects in children

This section discusses potential health effects from exposures during the period from conception to maturity at 18 years of age in humans.

Children can be exposed to cobalt in the same ways as adults. In addition, cobalt may be transferred from the pregnant mother to the fetus or from the mother to the infant in the breast milk. Children may be affected by cobalt the same ways as adults. Studies in animals have suggested that children may absorb more cobalt from foods and liquids containing cobalt than adults. Babies exposed to radiation while in their mother's womb are believed to be much more sensitive to the effects of radiation than adults.

Reducing risk of exposure to cobalt

If your doctor finds that you have been exposed to significant amounts of cobalt, ask whether your children might also be exposed. Your doctor might need to ask your state health department to investigate.

Since cobalt is naturally found in the environment, people cannot avoid being exposed to it. However, the relatively low concentrations present do not warrant any immediate steps to reduce exposure. If you are accidentally exposed to large amounts of cobalt, consult a physician immediately.

Children living near waste sites containing cobalt are likely to be exposed to higher environmental levels of cobalt through breathing, touching soil, and eating contaminated soil. Some children eat a lot of dirt. You should discourage your children from eating dirt. Make sure they wash their hands frequently and before eating. Discourage your children from putting their hands in their mouths or hand-to-mouth activity.

You are unlikely to be exposed to high levels of radioactive cobalt unless you are exposed as part of a radiotherapy treatment, there is an accident involving a cobalt sterilization or radiotherapy unit, or there is an accidental release from a nuclear power plant. In such cases, follow the advice of public health officials who will publish guidelines for reducing exposure to radioactive material when necessary. Workers who work near or with radioactive cobalt should follow the workplace safety guidelines of their institution carefully to reduce the risk of accidental irradiation.

Medical tests for exposure to cobalt

We have reliable tests that can measure cobalt in the urine and the blood for periods up to a few days after exposure. The amount of cobalt in your blood or urine can be used to estimate how much cobalt you had taken into your body. The tests are not ableto accurately predict potential health effects following exposure to cobalt.

It is difficult to determine whether a person has been exposed only to external radiation from radioactive cobalt unless the radiation dose was rather large. Health professionals examining people who have health problems similar to those resulting from radiation exposure would need to rely on additional information in order to establish if such people had been near a source of radioactivity. It is relatively easy to determine whether a person has been internally exposed to radioactive cobalt.

Further Reading

Disclaimer: This article is taken wholly from, or contains information that was originally published by, the Agency for Toxic Substances and Disease Registry. Topic editors and authors for the Encyclopedia of Earth may have edited its content or added new information. The use of information from the Agency for Toxic Substances and Disease Registry should not be construed as support for or endorsement by that organization for any new information added by EoE personnel, or for any editing of the original content.



(2008). Health effects of cobalt. Retrieved from


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